RNA Modification and Processing

Welcome to Transregio 319 RMaP

What is RMaP?

Transregio 319 RMaP is a joint venture combining:

Molecular Biology, Biochemistry, Cellular Biology, Chemical Biology, Biophysical Chemistry, Structural Biology, Developmental Biology, Genetics, Bioinformatics.

Principal Investigators of RMaP

Fabian Barthels

JGU

Falk Butter

JGU
A03, C03

Tamer Butto

JGU

Prof. Dr. Alexander Dalpke

TU-Dresden
A03

Prof. Dr. Christoph Dieterich

Uni-HD
B01, C02

Prof. Dr. Michaela Frye

UDKFZ
A01

Prof. Dr. Mark Helm

JGU
A05, C01, C03

Dr. Martin Hengesbach

JGU
B06

Prof. Dr. Andreas Hildebrandt

JGU
C01, C02

Prof. Dr. Andres Jäschke

Uni-HD
A02, C03

Prof. Dr. René Ketting

JGU
B04

Dr. Julian König

JGU
B01

Prof. Dr. Frank Lyko

DKFZ
A01

Prof. Dr. F. Nina Papasvasiliou

DKFZ
A04

Dr. Jirka Peschek

Uni-HD
A06

Prof. Dr. Jean-Yves Roignant

JGU
B01

Dr. Alessia Ruggieri

Uni-HD
A05, IRTG

Prof. Dr. Tanja Schirmeister

JGU
A01

Bertil Schmidt, Prof. Dr.

JGU
C01

Prof. Dr. Irmgard Sinning

Uni-HD
B03

Prof. Dr. Dr. Georg Stöcklin

Uni-HD
A04

Dr. Francesca Tuorto

Uni-HD
A06

Dr. Marie-Luise Winz

JGU
B05

Structure of RMaP

A „Modificationslook for Processing“

B „Processing looks for Modifications“

C „New RNA Technology for RMaP“

TRR Speaker Office

Prof. Dr. Mark Helm

Speaker

Dr. Marion Stemke

Executive officer and Coordinator

Claudia Alihodzic

Administrator TRR319

Members of the Scientific Board

Recent publications from the TRR 319

Wierczeiko A, Pastore S, Mündnich S, Busch AM, Dietrich V, Helm M, Butto T, Gerber S. NanopoReaTA: a user-friendly tool for nanopore-seq real-time transcriptional analysis. Bioinformatics. 2023 Aug 7:btad492. doi: 10.1093/bioinformatics/btad492. Epub ahead of print. PMID: 37549052.

García-Vílchez R, Añazco-Guenkova AM, Dietmann S, López J, Morón-Calvente V, D’Ambrosi S, Nombela P, Zamacola K, Mendizabal I, García-Longarte S, Zabala-Letona A, Astobiza I, Fernández S, Paniagua A, Miguel-López B, Marchand V, Alonso-López D, Merkel A, García-Tuñón I, Ugalde-Olano A, Loizaga-Iriarte A, Lacasa-Viscasillas I, Unda M, Azkargorta M, Elortza F, Bárcena L, Gonzalez-Lopez M, Aransay AM, Di Domenico T, Sánchez-Martín MA, De Las Rivas J, Guil S, Motorin Y, Helm M, Pandolfi PP, Carracedo A, Blanco S. METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer. Mol Cancer. 2023 Jul 29;22(1):119. doi: 10.1186/s12943-023-01809-8. PMID: 37516825; PMCID: PMC10386714.

Koch J, Neuberger M, Schmidt-Dengler M, Xu J, Carneiro VC, Ellinger J, Kriegmair MC, Nuhn P, Erben P, Michel MS, Helm M, Rodríguez-Paredes M, Nientiedt M, Lyko F. Reinvestigating the clinical relevance of the m6A writer METTL3 in urothelial carcinoma of the bladder. iScience. 2023 Jul 11;26(8):107300. doi: 10.1016/j.isci.2023.107300. PMID: 37554463; PMCID: PMC10405067.

Iyer KV, Müller M, Tittel LS, Winz ML. Molecular Highway Patrol for Ribosome Collisions. Chembiochem. 2023 Jun 29:e202300264. doi: 10.1002/cbic.202300264. Epub ahead of print. PMID: 37382189.

Yan L, Yin Z, Zhang H, Zhao Z, Wang M, Müller A, Kallenborn F, Wichmann A, Wei Y, Niu B, Schmidt B, Liu W. RabbitQCPlus 2.0: More Efficient and Versatile Quality Control for Sequencing Data. Methods. 2023 Jun 15:S1046-2023(23)00099-3. doi: 10.1016/j.ymeth.2023.06.007.  PMID: 37330158.

Fradera-Sola A, Nischwitz E, Bayer ME, Luck K, Butter F. RNA-dependent interactome allows network-based assignment of RNA-binding protein function. Nucleic Acids Res. 2023 Jun 9;51(10):5162-5176. doi: 10.1093/nar/gkad245. PMID: 37070168; PMCID: PMC10250244.

Zhang H, Song H, Xu X, Chang Q, Wang M, Wei Y, Yin Z, Schmidt B, Liu W. RabbitFX: Efficient Framework for FASTA/Q File Parsing on Modern Multi-Core Platforms. IEEE/ACM Trans Comput Biol Bioinform. 2023 Jun 5;20(3):2341-2348. doi: 10.1109/TCBB.2022.3219114. Epub 2023 Jun 5. PMID: 36327193.

Rücklé C, Körtel N, Basilicata MF, Busch A, Zhou Y, Hoch-Kraft P, Tretow K, Kielisch F, Bertin M, Pradhan M, Musheev M, Schweiger S, Niehrs C, Rausch O, Zarnack K, Keller Valsecchi CI, König J. RNA stability controlled by m6A methylation contributes to X-to-autosome dosage compensation in mammals. Nat Struct Mol Biol. 2023 May 18. doi: 10.1038/s41594-023-00997-7. PMID: 37202476.

For a constantly updated PubMed-library of TRR319 publications, please click here.

Upcoming Events

RMaP Retreat January 2024 @ Heidelberg

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RNA Biochemistry Meeting October 2023

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RMaP PhD Retreat @Rastatt

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