RNA Modification and Processing
Welcome to Transregio 319 RMaP
What is RMaP?
Transregio 319 RMaP is a joint venture combining:
Molecular Biology, Biochemistry, Cellular Biology, Chemical Biology, Biophysical Chemistry, Structural Biology, Developmental Biology, Genetics, Bioinformatics.
Principal Investigators of RMaP
Fabian Barthels
JGU
Falk Butter
JGU A03, C03
Tamer Butto
JGU
Prof. Dr. Alexander Dalpke
Uni-HD A03
Prof. Dr. Christoph Dieterich
Uni-HD B01, C02
Prof. Dr. Michaela Frye
UDKFZ A01
Prof. Dr. Mark Helm
JGU A05, C01, C03
Dr. Martin Hengesbach
JGU B06
Prof. Dr. Andreas Hildebrandt
JGU C01, C02
Prof. Dr. Andres Jäschke
Uni-HD A02, C03
Prof. Dr. René Ketting
JGU B04
Dr. Julian König
JGU B01
Prof. Dr. Frank Lyko
DKFZ A01
Prof. Dr. F. Nina Papasvasiliou
DKFZ A04
Dr. Jirka Peschek
Uni-HD A06
Prof. Dr. Jean-Yves Roignant
JGU B01
Dr. Alessia Ruggieri
Uni-HD A05, IRTG
Prof. Dr. Tanja Schirmeister
JGU A01
Bertil Schmidt, Prof. Dr.
JGU C01
Prof. Dr. Irmgard Sinning
Uni-HD B03
Prof. Dr. Dr. Georg Stöcklin
Uni-HD A04
Dr. Francesca Tuorto
Uni-HD A06
Dr. Marie-Luise Winz
JGU B05
Structure of RMaP
A „Modificationslook for Processing“
B „Processing looks for Modifications“
C „New RNA Technology for RMaP“
TRR Speaker Office
Prof. Dr. Mark Helm
Speaker
Dr. Marion Stemke
Executive officer and Coordinator
Claudia Alihodzic
Administrator TRR319
Doris Ebeling
Administration & Equal Opportunity officer
Doris Gebhardt
Administration & Equal opportunity officer
Members of the Scientific Board
Recent publications from the TRR 319
Lorenzo JP, Molla L, Amro EM, Ibarra IL, Ruf S, Neber C, Gkougkousis C, Ridani J, Subramani PG, Boulais J, Harjanto D, Vonica A, Di Noia JM, Dieterich C, Zaugg JB, Papavasiliou FN. APOBEC2 safeguards skeletal muscle cell fate through binding chromatin and regulating transcription of non-muscle genes during myoblast differentiation. Proc Natl Acad Sci U S A. 2024 Apr 23;121(17):e2312330121. doi: 10.1073/pnas.2312330121. Epub 2024 Apr 16. PMID: 38625936.
Delaunay S, Helm M, Frye M. RNA modifications in physiology and
disease: towards clinical applications. Nat Rev Genet. 2024 Feb;25(2):104-
122. doi: 10.1038/s41576-023-00645-2. Epub 2023 Sep 15. PMID: 37714958
Motorin Y, Helm M. General Principles and Limitations for Detection of RNA
Modifications by Sequencing. Acc Chem Res. 2024 Feb 6;57(3):275-288.
doi: 10.1021/acs.accounts.3c00529. Epub 2023 Dec 8. PMID: 38065564;
PMCID: PMC1085194
Gerber, J.L., Morales Guzmán, S.I., Worf, L. Hubbe, P., Kopp, J. and
Peschek, J. Structural and mechanistic insights into activation of the
human RNA ligase RTCB by Archease. Nat Commun 15, 2378 (2024).
https://doi.org/10.1038/s41467-024-46568-2. PMCID: PMC10944509
Bessler L, Groß J, Kampf CJ, Opatz T, Helm M. Reversible oxidative
dimerization of 4-thiouridines in tRNA isolates. RSC Chem Biol. 2024 Feb
1;5(3):216-224. doi: 10.1039/d3cb00221g. PMID: 38456039; PMCID:
PMC10915967.
Jörg M, Plehn JE, Kristen M, Lander M, Walz L, Lietz C, Wijns J, Pichot F,
Rojas-Charry L, Wirtz Martin KM, Ruffini N, Kreim N, Gerber S, Motorin Y,
Endres K, Rossmanith W, Methner A, Helm M, Friedland K. N1-
methylation of adenosine (m1A) in ND5 mRNA leads to complex I
dysfunction in Alzheimer’s disease. Mol Psychiatry. 2024 Jan 29. doi:
10.1038/s41380-024-02421-y. Epub ahead of print. PMID: 38287100
A continuously updated publication list can be found here.
