RNA Modification and Processing

Welcome to Transregio 319 RMaP

4th Symposium on Nucleic Acid Modifications

Symposium website

What is RMaP?

Transregio 319 RMaP is a joint venture combining:

Molecular Biology, Biochemistry, Cellular Biology, Chemical Biology, Biophysical Chemistry, Structural Biology, Developmental Biology, Genetics, Bioinformatics.

Principal Investigators of RMaP

Dr. Fabian Barthels

JGU

Bild P.B.
Prof. Dr. Petra Beli

JGU

Dr. Falk Butter

JGU
A03, C03

Dr. Tamer Butto

JGU

Prof. Dr. Alexander Dalpke

Uni-HD
A03

Prof. Dr. Christoph Dieterich

Uni-HD
B01, C02

Prof. Dr. Kristina Friedland

JGU

Prof. Dr. Michaela Frye

DKFZ
A01

Prof. Dr. Susanne Gerber

JGU

Prof. Dr. Mark Helm

JGU
A05, C01, C03

Dr. Martin Hengesbach

JGU
B06

Prof. Dr. Andreas Hildebrandt

JGU
C01, C02

Prof. Dr. Claudia Höbartner

JMU

Prof. Dr. Andres Jäschke

Uni-HD
A02, C03

Prof. Dr. René Ketting

JGU
B04

Prof. Dr. Julian König

JMU
B01

Prof. Dr. Frank Lyko

DKFZ
A01

Prof. Dr. F. Nina Papasvasiliou

DKFZ
A04

Dr. Jirka Peschek

Uni-HD
A06

Prof. Dr. Jean-Yves Roignant

JGU
B01

Dr. Alessia Ruggieri

Uni-HD
A05, IRTG

Jun.-Prof. Dr. Lauren Saunders

Uni-HD

Prof. Dr. Tanja Schirmeister

JGU
A01

Prof. Dr. Bertil Schmidt

JGU
C01

Prof. Dr. Irmgard Sinning

Uni-HD
B03

Prof. Dr. Dr. Georg Stöcklin

Uni-HD
A04

Dr. Francesca Tuorto

Uni-HD
A06

Jun.-Prof. Dr. Marie-Luise Winz

JGU
B05

Structure of RMaP

A „Modificationslook for Processing“

B „Processing looks for Modifications“

C „New RNA Technology for RMaP“

TRR Speaker Office

Prof. Dr. Mark Helm

Speaker

Dr. Marion Stemke

Executive officer and Coordinator

Claudia Alihodzic

Administrator TRR319

Doris Ebeling

Administration & Equal Opportunity officer

Doris Gebhardt

Administration & Equal opportunity officer

Members of the Scientific Board

Recent publications from the TRR 319

Wu CC, Naarmann-de Vries IS, Hartmann J, Nidoieva Z, Kopietz K, Marchand V, Özrendeci Z, Lindner D, Schelchshorn S, Flad S, Frye M, Papavasiliou N, Schirmeister T, Stoecklin G, Schott J, Motorin Y, Tuorto F, Dieterich C, Helm M, Ruggieri A. The two-step purification method ViREn identifies a single NSUN6-mediated 5-methylcytosine modification promoting dengue virus RNA genome turnover. bioRxiv DOI:1101/2025.03.17.643699 preprint.

Kopietz K, Raorane K, Guo W, Flegler F, Bourguignon V, Thuillier Q, Kilz LM, Weber M, Marchand V, Reuter K, Tuorto F, Helm M, Motorin Y. TGT Damages its Substrate tRNAs by the Formation of Abasic Sites in the Anticodon Loop. J Mol Biol. 2025 Feb 25:169000. DOI: 1016/j.jmb.2025.169000. Epub ahead of print. PMID: 40011082.

Gonzalez-Jabalera P, Jäschke A. Flavin adenine dinucleotide (FAD) as a non-canonical RNA cap: Mechanisms, functions, and emerging insights. Arch Biochem Biophys. 2025 Apr;766:110326. DOI: 10.1016/j.abb.2025.110326. Epub 2025 Feb 5. PMID: 39921141.

Nidoieva Z, Sabin MO, Dewald T, Weldert AC, Hoba SN, Helm M, Barthels F. A microscale thermophoresis-based enzymatic RNA methyltransferase assay enables the discovery of DNMT2 inhibitors. Commun Chem. 2025 Feb 3;8(1):32. doi: 10.1038/s42004-025-01439-9. PMCID: PMC11790956  DOI: 1038/s42004-025-01439-9

Morishima T, Fakruddin M, Kanamori Y, Masuda T, Ogawa A, Wang Y, Schoonenberg VAC, Butter F, Arima Y, Akaike T, Moroishi T, Tomizawa K, Suda T, Wei FY, Takizawa H. Mitochondrial translation regulates terminal erythroid differentiation by maintaining iron homeostasis. Sci Adv. 2025 Feb 21;11(8):eadu3011. Epub 2025 Feb 21. PMID: 39983002; PMCID: PMC11844735  DOI: 1126/sciadv.adu3011

He YM, Burkard A, Wu CS, Jin XY, Liu L, Helm M, Cheng L. A Direct Chemical Repair of Etheno-Type RNA Damages. Angew Chem Int Ed Engl. 2025 Jan 15;64(3):e202415417. DOI: 1002/anie.202415417 Epub 2024 Dec 2. PMID: 39589841.

Xu J, Koch J, Schmidt C, Nientiedt M, Neuberger M, Erben P, Michel MS, Rodríguez-Paredes M, Lyko F. Loss of YTHDC1 m6A reading function promotes invasiveness in urothelial carcinoma of the bladder. Exp Mol Med. 2025 Feb;57(1):118-130.  DOI: 1038/s12276-024-01377-x. Epub 2025 Jan 1. PMID: 39741187; PMCID: PMC11799412.

Soni K, Horvath A, Dybkov O, Schwan M, Trakansuebkul S, Flemming D, Wild K, Urlaub H, Fischer T, Sinning I. Structures of aberrant spliceosome intermediates on their way to disassembly. Nat Struct Mol Biol. 2025 Jan 20. DOI: 10.1038/s41594-024-01480-7. Epub ahead of print. PMID: 39833470.

A continuously updated publication list can be found here.

Upcoming Events

4th Symposium on Nucleic Acid Modifications

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2nd “Medicinal mRNA and Immunity” 04.2024

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Career crafting for females

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Leading Successfully

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RMaP Retreat February 2025 @ Heidelberg

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Symposium “Pharmazie 2040”

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