RNA Modification and Processing
Welcome to Transregio 319 RMaP
What is RMaP?
Transregio 319 RMaP is a joint venture combining:
Molecular Biology, Biochemistry, Cellular Biology, Chemical Biology, Biophysical Chemistry, Structural Biology, Developmental Biology, Genetics, Bioinformatics.
Structure of RMaP
A „Modificationslook for Processing“
B „Processing looks for Modifications“

C „New RNA Technology for RMaP“
TRR Speaker Office

Prof. Dr. Mark Helm
Speaker

Dr. Marion Stemke
Executive officer and Coordinator

Claudia Alihodzic
Administrator TRR319

Doris Ebeling
Administration & Equal Opportunity officer

Doris Gebhardt
Administration & Equal opportunity officer
Members of the Scientific Board
Recent publications from the TRR 319
Wu CC, Naarmann-de Vries IS, Hartmann J, Nidoieva Z, Kopietz K, Marchand V, Özrendeci Z, Lindner D, Schelchshorn S, Flad S, Frye M, Papavasiliou N, Schirmeister T, Stoecklin G, Schott J, Motorin Y, Tuorto F, Dieterich C, Helm M, Ruggieri A. The two-step purification method ViREn identifies a single NSUN6-mediated 5-methylcytosine modification promoting dengue virus RNA genome turnover. bioRxiv DOI:1101/2025.03.17.643699 preprint.
Kopietz K, Raorane K, Guo W, Flegler F, Bourguignon V, Thuillier Q, Kilz LM, Weber M, Marchand V, Reuter K, Tuorto F, Helm M, Motorin Y. TGT Damages its Substrate tRNAs by the Formation of Abasic Sites in the Anticodon Loop. J Mol Biol. 2025 Feb 25:169000. DOI: 1016/j.jmb.2025.169000. Epub ahead of print. PMID: 40011082.
Gonzalez-Jabalera P, Jäschke A. Flavin adenine dinucleotide (FAD) as a non-canonical RNA cap: Mechanisms, functions, and emerging insights. Arch Biochem Biophys. 2025 Apr;766:110326. DOI: 10.1016/j.abb.2025.110326. Epub 2025 Feb 5. PMID: 39921141.
Nidoieva Z, Sabin MO, Dewald T, Weldert AC, Hoba SN, Helm M, Barthels F. A microscale thermophoresis-based enzymatic RNA methyltransferase assay enables the discovery of DNMT2 inhibitors. Commun Chem. 2025 Feb 3;8(1):32. doi: 10.1038/s42004-025-01439-9. PMCID: PMC11790956 DOI: 1038/s42004-025-01439-9
Morishima T, Fakruddin M, Kanamori Y, Masuda T, Ogawa A, Wang Y, Schoonenberg VAC, Butter F, Arima Y, Akaike T, Moroishi T, Tomizawa K, Suda T, Wei FY, Takizawa H. Mitochondrial translation regulates terminal erythroid differentiation by maintaining iron homeostasis. Sci Adv. 2025 Feb 21;11(8):eadu3011. Epub 2025 Feb 21. PMID: 39983002; PMCID: PMC11844735 DOI: 1126/sciadv.adu3011
He YM, Burkard A, Wu CS, Jin XY, Liu L, Helm M, Cheng L. A Direct Chemical Repair of Etheno-Type RNA Damages. Angew Chem Int Ed Engl. 2025 Jan 15;64(3):e202415417. DOI: 1002/anie.202415417 Epub 2024 Dec 2. PMID: 39589841.
Xu J, Koch J, Schmidt C, Nientiedt M, Neuberger M, Erben P, Michel MS, Rodríguez-Paredes M, Lyko F. Loss of YTHDC1 m6A reading function promotes invasiveness in urothelial carcinoma of the bladder. Exp Mol Med. 2025 Feb;57(1):118-130. DOI: 1038/s12276-024-01377-x. Epub 2025 Jan 1. PMID: 39741187; PMCID: PMC11799412.
Soni K, Horvath A, Dybkov O, Schwan M, Trakansuebkul S, Flemming D, Wild K, Urlaub H, Fischer T, Sinning I. Structures of aberrant spliceosome intermediates on their way to disassembly. Nat Struct Mol Biol. 2025 Jan 20. DOI: 10.1038/s41594-024-01480-7. Epub ahead of print. PMID: 39833470.
A continuously updated publication list can be found here.