RNA Modification and Processing
Welcome to Transregio 319 RMaP
What is RMaP?
Transregio 319 RMaP is a joint venture combining:
Molecular Biology, Biochemistry, Cellular Biology, Chemical Biology, Biophysical Chemistry, Structural Biology, Developmental Biology, Genetics, Bioinformatics.
Principal Investigators of RMaP
Dr. Fabian Barthels
JGU
Prof. Dr. Petra Beli
JGU
Dr. Falk Butter
JGU A03, C03
Dr. Tamer Butto
JGU
Prof. Dr. Alexander Dalpke
Uni-HD A03
Prof. Dr. Christoph Dieterich
Uni-HD B01, C02
Prof. Dr. Kristina Friedland
JGU
Prof. Dr. Michaela Frye
DKFZ A01
Prof. Dr. Susanne Gerber
JGU
Prof. Dr. Mark Helm
JGU A05, C01, C03
Dr. Martin Hengesbach
JGU B06
Prof. Dr. Andreas Hildebrandt
JGU C01, C02
Prof. Dr. Claudia Höbartner
JMU
Prof. Dr. Andres Jäschke
Uni-HD A02, C03
Prof. Dr. René Ketting
JGU B04
Prof. Dr. Julian König
JMU B01
Prof. Dr. Frank Lyko
DKFZ A01
Prof. Dr. F. Nina Papasvasiliou
DKFZ A04
Dr. Jirka Peschek
Uni-HD A06
Prof. Dr. Jean-Yves Roignant
JGU B01
Dr. Alessia Ruggieri
Uni-HD A05, IRTG
Jun.-Prof. Dr. Lauren Saunders
Uni-HD
Prof. Dr. Tanja Schirmeister
JGU A01
Prof. Dr. Bertil Schmidt
JGU C01
Prof. Dr. Irmgard Sinning
Uni-HD B03
Prof. Dr. Dr. Georg Stöcklin
Uni-HD A04
Dr. Francesca Tuorto
Uni-HD A06
Jun.-Prof. Dr. Marie-Luise Winz
JGU B05
Structure of RMaP
A „Modificationslook for Processing“
B „Processing looks for Modifications“
C „New RNA Technology for RMaP“
TRR Speaker Office
Prof. Dr. Mark Helm
Speaker
Dr. Marion Stemke
Executive officer and Coordinator
Claudia Alihodzic
Administrator TRR319
Doris Ebeling
Administration & Equal Opportunity officer
Doris Gebhardt
Administration & Equal opportunity officer
Members of the Scientific Board
Recent publications from the TRR 319
Wu CC, Naarmann-de Vries IS, Hartmann J, Nidoieva Z, Kopietz K, Marchand V, Özrendeci Z, Lindner D, Schelchshorn S, Flad S, Frye M, Papavasiliou N, Schirmeister T, Stoecklin G, Schott J, Motorin Y, Tuorto F, Dieterich C, Helm M, Ruggieri A. The two-step purification method ViREn identifies a single NSUN6-mediated 5-methylcytosine modification promoting dengue virus RNA genome turnover. bioRxiv DOI:1101/2025.03.17.643699 preprint.
Kopietz K, Raorane K, Guo W, Flegler F, Bourguignon V, Thuillier Q, Kilz LM, Weber M, Marchand V, Reuter K, Tuorto F, Helm M, Motorin Y. TGT Damages its Substrate tRNAs by the Formation of Abasic Sites in the Anticodon Loop. J Mol Biol. 2025 Feb 25:169000. DOI: 1016/j.jmb.2025.169000. Epub ahead of print. PMID: 40011082.
Gonzalez-Jabalera P, Jäschke A. Flavin adenine dinucleotide (FAD) as a non-canonical RNA cap: Mechanisms, functions, and emerging insights. Arch Biochem Biophys. 2025 Apr;766:110326. DOI: 10.1016/j.abb.2025.110326. Epub 2025 Feb 5. PMID: 39921141.
Nidoieva Z, Sabin MO, Dewald T, Weldert AC, Hoba SN, Helm M, Barthels F. A microscale thermophoresis-based enzymatic RNA methyltransferase assay enables the discovery of DNMT2 inhibitors. Commun Chem. 2025 Feb 3;8(1):32. doi: 10.1038/s42004-025-01439-9. PMCID: PMC11790956 DOI: 1038/s42004-025-01439-9
Morishima T, Fakruddin M, Kanamori Y, Masuda T, Ogawa A, Wang Y, Schoonenberg VAC, Butter F, Arima Y, Akaike T, Moroishi T, Tomizawa K, Suda T, Wei FY, Takizawa H. Mitochondrial translation regulates terminal erythroid differentiation by maintaining iron homeostasis. Sci Adv. 2025 Feb 21;11(8):eadu3011. Epub 2025 Feb 21. PMID: 39983002; PMCID: PMC11844735 DOI: 1126/sciadv.adu3011
He YM, Burkard A, Wu CS, Jin XY, Liu L, Helm M, Cheng L. A Direct Chemical Repair of Etheno-Type RNA Damages. Angew Chem Int Ed Engl. 2025 Jan 15;64(3):e202415417. DOI: 1002/anie.202415417 Epub 2024 Dec 2. PMID: 39589841.
Xu J, Koch J, Schmidt C, Nientiedt M, Neuberger M, Erben P, Michel MS, Rodríguez-Paredes M, Lyko F. Loss of YTHDC1 m6A reading function promotes invasiveness in urothelial carcinoma of the bladder. Exp Mol Med. 2025 Feb;57(1):118-130. DOI: 1038/s12276-024-01377-x. Epub 2025 Jan 1. PMID: 39741187; PMCID: PMC11799412.
Soni K, Horvath A, Dybkov O, Schwan M, Trakansuebkul S, Flemming D, Wild K, Urlaub H, Fischer T, Sinning I. Structures of aberrant spliceosome intermediates on their way to disassembly. Nat Struct Mol Biol. 2025 Jan 20. DOI: 10.1038/s41594-024-01480-7. Epub ahead of print. PMID: 39833470.
A continuously updated publication list can be found here.
