Projects

RMaP ist subdivided in three academic areas, the Integrated Research Training Group, and the central administration.

A01

Functional roles of 5-methylcytosine (m5C) in regulating cell fate in normal tissues and human disease

Molecular Biology, Cell Biology, Medicinal Chemistry

Prof. Dr. Frank Lyko
Division of Epigenetics
DKFZ
Heidelberg

Prof. Dr. Michaela Frye
Division of Mechanisms
Regulating Gene Expression
DKFZ
Heidelberg

Prof. Dr. Tanja Schirmeister
Institute of Pharmaceutical and Biomedical Sciences
JGU Mainz

A02

Multiple capping and decapping pathways for NAD-modified RNAs and their relation of RNA processing

Chemical Biology, Biochemistry

Prof. Dr. Andres Jäschke,
Institute of Pharmacy and Molecular Biotechnology
Heidelberg University

A03

Impact of RNA modifications on RNA processing and stimulation of innate immune Toll-like receptors 7/8

Immunology, Biochemistry Molecular Biology

Prof. Dr. Alexander Dalpke
TU
Dresden

Dr. Falk Butter
Institute of Molecular Biology (IMB),
JGU
Mainz

A04

Ensemble analysis of mRNA editing, modification and processing in macrophages

Cell Biology, Molecular Biology,

Prof. Dr. F. Nina Papavasiliou
Division of Immune Diversity
DKFZ
Heidelberg

Prof. Dr. Dr. Georg Stöcklin,
Center for Molecular Biology (ZMBH)
Heidelberg University

A05

Dynamics of modifications and processing of RNAs in the flavivirus replication cycle

Immunology, Virology, Analytical Chemistry

Dr. Alessia Ruggieri
Dept. of Infectious Diseases
Heidelberg University

Prof. Dr. Mark Helm
Institute of Pharmaceutical and Biomedical Sciences
JGU
Mainz

A06

Interplay between tRNA splicing and tRNA modifications

Molecular Biology, Biochemistry, Structural Biology, Cell Biology

Dr. Jirka Peschek
Biochemistry Center (BZH)
Heidelberg University

Dr. Francesca Tuorto
Department of Biochemisty
Medical Faculty Mannheim
Heidelberg University

Project area B:

B01

The mechanistic and functional impact of RNA modifications on alternative splicing

Molecular Biology, Cell Biology, Bioinformatics

Prof. Dr. Christoph Dieterich
Section of Bioinformatics and Systems Cardiology
Heidelberg and German Center for Cardiovascular Research (DZHK)
Heidelberg University

Dr. Julian König
Institute of Molecular Biology (IMB)
JGU
Mainz

Prof. Dr. Jean-Yves Roignant
Center for Integrative Genomics
Université de Lausanne 1015 Lausanne
Switzerland / Institute of Pharmaceutical and Biomedical Sciences
JGU
Mainz

B03

Molecular insights into the role of MTREC in ncRNA processing and degradation

Molecular Biology, Structural Biology

Prof. Dr. Irmgard Sinning
Biochemistry-Center (BZH)
Heidelberg University

B04

Identification and processing of piRNA precursors in C. elegans

Molecular Biology, Cell Biology, Genetics

Prof. Dr. René F. Ketting
Institute of Molecular Biology (IMB)
JGU
Mainz

B05

Mismodification of tRNA in no-go decay and other co-translational quality control pathways

Molecular Biology, Biochemistry, Cell Biology, Bioinformatics

Dr. Marie-Luise Winz
Institute of Pharmaceutical and Biomedical Sciences
JGU
Mainz

B06

Assembly, activity, and structural dynamics of eukaryotic H/ACA complexes

Molecular Biology, Biochemistry

Dr. Martin Hengesbach
Institute of Pharmaceutical and Biomedical Sciences
JGU
Mainz

Project area C:

C01

Novel modification mapping techniques and efficient RNA-Seq data management

Bioinformatics, Chemical Biology

Prof. Dr. Bertil Schmidt
Institute of Computer Science
JGU
Mainz

Prof. Dr. Mark Helm
Institute of Pharmaceutical and Biomedical Sciences
JGU
Mainz

Prof. Dr. Andreas Hildebrandt
Institute of Computer Science
JGU
Mainz

C02

SCI-MODOM – Management, integration and real-time analytics of RNA modification data

Bioinformatics

Prof. Dr. Christoph Dieterich
Section of Bioinformatics and Systems Cardiology
Heidelberg and German Center for Cardiovascular Research (DZHK)
Heidelberg University

Prof. Dr. Andreas Hildebrandt
Institute of Computer Science
Mainz

C03

Mass spectrometry of RNA and proteins in modified RNPs

Biochemistry, Analytical Chemistry

Prof. Dr. Andres Jäschke
Institute of Pharmacy and Molecular Biotechnology
Heidelberg University

Dr. Falk Butter
Institute of Molecular Biology (IMB)
JGU
Mainz

Prof. Dr. Mark Helm
Institute of Pharmaceutical and Biomedical Sciences
JGU
Mainz

Project area D: Integrated Research Training Group

D

Integrated Research Training Group

Dr. Alessia Ruggieri
Dept. of Infectious Diseases
Heidelberg University

Project area Z:

Z

Administration and organization

Prof. Dr. Mark Helm
Institute of Pharmaceutical and Biomedical Sciences
JGU
Mainz