Projects

RMaP ist subdivided in three academic areas, the Integrated Research Training Group, and the central administration.

A01

Mechanistic Insights into tRNA Guanosine Modifications m¹G and m⁷G

Molecular Biology, Cell Biology, Medicinal Chemistry

Dr. Barthels
Institute of Pharmaceutical and Biomedical Sciences
JGU
Mainz

Prof. Dr. Michaela Frye
Division of Mechanisms
Regulating Gene Expression
DKFZ
Heidelberg

A02

The biological relevance of NAD⁺-capping of RNA

Chemical Biology, Biochemistry

Prof. Dr. Andres Jäschke,
Institute of Pharmacy and Molecular Biotechnology
Heidelberg University

A03

How RNA modifications affect RNA processing and TLR8 stimulation in innate immune cells

Immunology, Biochemistry Molecular Biology

Prof. Dr. Alexander Dalpke
TU
Dresden

Prof. Dr. Claudia Höbartner
Institute of Organic Chemistry and Center for Nanosystems Chemistry
JMU
Würzburg

A04

Ensemble analysis of mRNA editing, modification and processing in macrophages

Cell Biology, Molecular Biology,

Prof. Dr. F. Nina Papavasiliou
Division of Immune Diversity
DKFZ
Heidelberg

Prof. Dr. Dr. Georg Stöcklin,
Center for Molecular Biology (ZMBH)
Heidelberg University

A05

Dynamics of modifications and processing of RNAs in the flavivirus replication cycle

Immunology, Virology, Analytical Chemistry

Dr. Alessia Ruggieri
Dept. of Infectious Diseases
Heidelberg University

Prof. Dr. Mark Helm
Institute of Pharmaceutical and Biomedical Sciences
JGU
Mainz

A06

Interplay between tRNA processing and tRNA modifications

Molecular Biology, Biochemistry, Structural Biology, Cell Biology

Dr. Jirka Peschek
Biochemistry Center (BZH)
Heidelberg University

Dr. Francesca Tuorto
Department of Biochemisty
Medical Faculty Mannheim
Heidelberg University

A07

Uncovering the role of m¹A methylation in mitochondrial mRNA stability, translation, and function

Prof. Dr. Kristina Friedland
Institute of Pharmaceutical and Biomedical Sciences
JGU
Mainz

Prof. Dr. Susanne Gerber
Institute of Human Genetics
University Medicine
Mainz

A08

How VIRMA Shapes m⁶A-Driven Transcript Modifications

Prof. Dr. Michaela Frye
Division of Mechanisms
Regulating Gene Expression
DKFZ
Heidelberg

Dr. Martin Hengesbach
Institute of Pharmaceutical and Biomedical Sciences
JGU
Mainz

Project area B:

B03

Molecular insights into the role of MTREC in ncRNA processing and degradation

Molecular Biology, Structural Biology

Prof. Dr. Irmgard Sinning
Biochemistry-Center (BZH)
Heidelberg University

B04

Identification and processing of piRNA precursors in C. elegans

Molecular Biology, Cell Biology, Genetics

Prof. Dr. René F. Ketting
Institute of Molecular Biology (IMB)
JGU
Mainz

B07

Mechanistic studies on the interplay of rRNA modification and processing with ribosome biogenesis, structure and function

Dr. Tamer Butto
Institute of Pharmaceutical and Biomedical Sciences
JGU
Mainz

Prof. Dr. Irmgard Sinning
Biochemistry-Center (BZH)
Heidelberg University

Jun.-Prof. Dr. Marie-Luise Winz
Institute of Pharmaceutical and Biomedical Sciences
JGU
Mainz

B08

The role of P-bodies in m⁶A-mediated RNA decay

Prof. Dr. Julian König
Biochemistry and RNA-Biology
JMU
Würzburg

Prof. Dr. Frank Lyko
Division of Epigenetics
DKFZ
Heidelberg

Project area C:

C01

Novel modification mapping techniques and their application to single cell epitranscriptomics

Bioinformatics, Chemical Biology

Prof. Dr. Mark Helm
Institute of Pharmaceutical and Biomedical Sciences
JGU
Mainz

Jun.-Prof. Dr. Lauren Saunders
Centre For Organismal Studies
Developmental Genomics
Heidelberg University

C02

Sci-ModoM – the lighthouse database of transcriptome-wide RNA modification and processing

Bioinformatics

Prof. Dr. Christoph Dieterich
Section of Bioinformatics and Systems Cardiology
Heidelberg and German Center for Cardiovascular Research (DZHK)
Heidelberg University

C03

Mass spectrometry of RNA and proteins in modified RNPs

Biochemistry, Analytical Chemistry

Prof. Dr. Mark Helm
Institute of Pharmaceutical and Biomedical Sciences
JGU
Mainz

Prof. Dr. Petra Beli
Institute of Molecular Biology (IMB)
JGU
Mainz

C04

Precision Nanopore sequencing of RNA modifications and processing events

Prof. Dr. Christoph Dieterich
Section of Bioinformatics and Systems Cardiology
Heidelberg and German Center for Cardiovascular Research (DZHK)
Heidelberg University

Prof. Dr. Susanne Gerber
Institute of Human Genetics
University Medicine
Mainz

Project area D: Integrated Research Training Group

D

Integrated Research Training Group

Dr. Alessia Ruggieri
Dept. of Infectious Diseases
Heidelberg University

Project area Z:

Z

Administration and organization

Prof. Dr. Mark Helm
Institute of Pharmaceutical and Biomedical Sciences
JGU
Mainz